The talk show host, who endorsed Hillary Clinton’s campaign, has said she is not ruling out throwing her hat into the ring.
Winfrey said Donald Trump’s election had made her re-evaluate her previous scepticism about running for President.
“I never considered the question even a possibility,” she told David Rubenstein on his Bloomberg Television programme when pressed about whether she might consider running.
“I just thought, ‘Oh… oh?'”
Referring to Mr Trump, Mr Rubenstein said: “It’s clear you don’t need government experience to be elected president of the United States”.
“That’s what I thought,” she continued. “I thought, ‘Oh, gee, I don’t have the experience, I don’t know enough.’ And now I’m thinking, ‘Oh.'”
This marks a clear break from Winfrey’s past comments about becoming president. In January, she said she would never run.